Dengue (DF) and dengue hemorrhagic fever (DHF) are infections found in humid and sub tropical countries or areas. A cycle is maintained involving humans and the Aedes mosquito with four different dengue serotypes. The virus is caused by one of four closely related of the genus Flavivirus. Disease with one of these serotypes presents protection to only that of serotype for life. Persons who live within the dengue-endemic area can have in excess of dengue infection throughout their existence or lifetime. These infections are producing a spectrum of clinical illness ranging from a nonspecific viral syndrome to ruthless and fatal hemorrhagic disease.