Researchers from The University of Arizona in Tucson have discovered that a particular species of mosquito, the Aedes aegypti (the infamous dengue carrier), has quite a complex metabolic pathway. It requires its members to excrete toxic nitrogen after feasting on human blood. If they do not do this, they also fail to lay eggs which will eventually weaken and kill them.

Neat huh?

The team of researchers composed of leader Roger L. Miesfeld, members Patricia Y. Scaraffia, Guanhong Tan, Jun Isoe, BIO5 member Vicki H. Wysocki, and the late Michael A. Wells will be publishing the results of their study in the January 15 issue of the Proceedings of the National Academy of Sciences.

The group believes that further development of this project, such as finding a way to keep the mosquitoes from excreting nitrogen, will help eradicate the deadly disease

Source: CCNMag

Some 300 medical teams from all over the world has been sent across Asia to fight and prevent outbreaks of Dengue. The BBC News was told by Mumbai officials that 250 people had been rushed to various Mumbai hospitals stricken with Dengue fevers for the past several days. “They are all suffering from fever, Leptospirosis was suspected. There is no epidemic, though,” claims the source of the news. This was thwarted by the statement of a Mumbai Health officer who otherwise stated that Dengue fever was indeed a major concern in their country. Well actually isn’t it a major problem for practically everyone in the third world? 

According to the researchers at the Washington University School of Medicine in St. Louis,
their particular study and research have shown that antibody-dependent enhancement (ADE) of infection is actually able to be suppressed by C1q, a blood-borne immune system compound.

Er, let�s put it on a more understandable context.

This epidemiological and laboratory-based ADE study is relevant in helping the control of viral disease outbreaks. Public health experts and clinicians may someday be able to design more effective aid systems such as safer and more effective vaccines.

The results of this study may also be the key to formulating a working dengue vaccine. Scientists have theorized that dengue patients become more vulnerable to another infection because of inadequate antibodies to eradicate the dengue virus when it returned. However, when researchers tried to simulate this particular phenomenon in animal models, they were unable to.

Source: Newswise

There may be hope for dengue cure after all. Unfortunately, we all still have to wait a few more years � well, until 2012. That�s how long until the vaccine Tetravalent, manufactured by drug company Sanofi will be ready to be submitted for approval.

According to reports of the drug trial conducted in the United States, the vaccine was found to be 100% effective against all four serotypes of the virus that are responsible for the deadly dengue fever. Sanofi plans also to do clinical trials of said vaccine in Asia and Latin America. Now isn�t this good news?

Source: News Medical

Dengue is usually associated with poorer tropical countries. The disease leads to a sudden onset of fever with severe headaches, muscle and joint pains, as well as rashes. According to the AFP, the mosquito viral called Dengue fever has instantly become a significant public viral outbreak in Thailand, where a recent epidemic resulted in 63,000 cases and 91 deaths nationwide. Health education is crucial to the minimization of the disease. To make sure that people understand the cause of infection and the ways to prevent people from catching the virus is the best step to combat Dengue. Health education for dengue control should be provided in primary schools and community health centers as suggested by the National Dengue Control Program.

 

There is no detailed or specific action for dengue fever, but close medical awareness and clinical management revives the lives of many patients. At the present time, the only technique of controlling dengue and DHF is to battle the vector mosquito all the way through chemical control and environmental management. Community-based cleaning operations remove tyres, bottles, cans and other objects that catch and keep hold of water, get free of possible breeding sites for vector mosquitoes. Larval surroundings are too treated with insecticide. Insecticidal space sprays, by means of vehicle-mounted or moveable machines, are used in many programmes for urgent situations and to  control the growth of adult mosquitoes.

The mosquito scourge is dependent on certain environmental conditions to survive and our meddling with nature as in the case of once arid lands, turning them into lush farmland may be responsible for spreading the disease. Mosquitoes thrive in tropical environments and with many tropical areas already infected, taming other places that used to be too harsh for them, where rainwater is so precious we try to collect each and every drop turning them into havens for the virus carrying mosquito. (more…)

Dengue infections have spread all over the world and in most cases, modern hospital management and care manages to get the patient back to normal health. The few who die from the disease are a unique bunch who develop a sort of shock-syndrome to the virus, with their bodies reacting so violently they present symptoms the alternate name of dengue is known, hemorrhagic fever that can result in death. (more…)

Dengue Hemorrhagic Fever(DHF) is actually an old virus that is considered to be one of the most deadliest the world over due to their ability to jump species. Spread by the Aedes Aegypti mosquito, that is differentiated by it’s daytime feeding habits, it has silently killed millions the world over. The incubation period is short accompanied by severe fever that usually lasts three days, after which, without proper monitoring and care death is sure to occur. Mostly restricted to areas that are in the tropics zone due to the inability of its host to survive in cold weather. Outbreaks have been well documented and a cure is still out of sight. The disease is however being tackled from different angles, one of them targets the disease at its source, the mosquito which can be infected with a virus that halves its lifespan thus lessening its ability to spread it by half. The danger came when man invented mass travel wherein people and machines could transport the disease carrying mosquitoes all over the globe.

Image Source: bp1.blogger.com

The worst kind of dengue is the shock syndrome, where your whole circulatory system just shuts down though it’s rare. Symptoms of dengue can vary but are often associated with a fever, headaches, joint pain and a rash. For most people it is not fatal. There is no specific treatment or vaccine for dengue fever. Once contracted, doctor’s advice is to take fluids and rest. The pathogenesis of dengue shock syndrome remains unclear. It is suggested that antibody-dependent enhancement is involved in these more serious conditions when infected the second time around with a different serotype of the virus. After an initial period of protection, antibodies from the primary infection can cross-react with other dengue virus serotypes but have waned to non-neutralizing levels leading to increased virus replication and immune activation including massive cytokine release also known as a cytokine storm.