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The worst kind of dengue is the shock syndrome, where your whole circulatory system just shuts down though it’s rare. Symptoms of dengue can vary but are often associated with a fever, headaches, joint pain and a rash. For most people it is not fatal. There is no specific treatment or vaccine for dengue fever. Once contracted, doctor’s advice is to take fluids and rest. The pathogenesis of dengue shock syndrome remains unclear. It is suggested that antibody-dependent enhancement is involved in these more serious conditions when infected the second time around with a different serotype of the virus. After an initial period of protection, antibodies from the primary infection can cross-react with other dengue virus serotypes but have waned to non-neutralizing levels leading to increased virus replication and immune activation including massive cytokine release also known as a cytokine storm.